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EPHX1_rs1051740
(Microsomal Epoxide Hydrolase)
Detoxification
Zhu, Q., Xing, W., Qian, B., von Dippe, P., Shneider, B. L., Fox, V. L., Levy, D. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim. Biophys. Acta 1638: 208-216, 2003. [PubMed: 12878321, related citations] [Full Text]
Zusterzeel, P. L. M., Peters, W. H. M., Visser, W., Hermsen, K. J. M., Roelofs, H. M. J., Steegers, E. A. P. A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. J. Med. Genet. 38: 234-237, 2001. [PubMed: 11283205, related citations] [Full Text]
FTO_rs9939609/ rs1121980 (Alpha-ketoglutarate-dependent dioxygenase FTO)
Healthy Weight Management
Church, C., Moir, L., McMurray, F., Girard, C., Banks, G. T., Teboul, L., Wells, S., Bruning, J. C., Nolan, P. M., Ashcroft, F. M., Cox, R. D. Overexpression of FTO leads to increased food intake and results in obesity. Nature Genet. 42: 1086-1092, 2010. [PubMed: 21076408, images, related citations] [Full Text]
Dina, C., Meyre, D., Gallina, S., Durand, E., Korner, A., Jacobson, P., Carlsson, L. M. S., Kiess, W., Vatin, V., Lecoeur, C., Delplanque, J., Vaillant, E., and 15 others. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genet. 39: 724-726, 2007. Note: Erratum: Nature Genet. 39: 1285 only, 2007. [PubMed: 17496892, related citations] [Full Text]